Novel 'split bladder' model to study micturition reflex in rats
نویسندگان
چکیده
منابع مشابه
Neuromodulation in a rat model of the bladder micturition reflex.
A rat model of bladder reflex contraction (BRC) was used to determine the optimal frequency and intensity of spinal nerve (SN) stimulation to produce neuromodulation of bladder activity and to assess the therapeutic mechanisms of this neuromodulation. In anesthetized female rats (urethane 1.2 g/kg ip), a wire electrode was used to produce bilateral stimulation of the L6 SN. A cannula was placed...
متن کاملCan intraurethral stimulation inhibit micturition reflex in normal female rats?
OBJECTIVE The study was designed to determine the effect of low frequency (2.5Hz) intraurethral electrical stimulation on bladder capacity and maximum voiding pressures. MATERIALS AND METHODS The experiments were conducted in 15 virgin female Sprague-Dawley rats (220-250g). The animals were anesthetized by intraperitoneal injection of urethane (1.5g/kg). Animal care and experimental procedure...
متن کاملComparison of neural targets for neuromodulation of bladder micturition reflex in the rat.
Spinal nerve (SN) stimulation inhibits the bladder rhythmic contraction (BRC) in anesthetized rats. This preparation was used to study the effects of electrical stimulation of the tibial nerve (TN) and the dorsal nerve of the clitoris (DNC) on BRC. Stimulation of the TN and DNC for 10 min produced a frequency- and intensity-dependent attenuation of the frequency of bladder contractions. As obse...
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Functional studies have demonstrated that adrenoceptor agonist-evoked relaxation is mediated primarily by 3-adrenergic receptors (ARs) in human bladder. Thus, the use of selective 3-AR agonists in the pharmacological treatment of overactive bladder is being explored. The present studies investigated the effects of a novel selective 3-AR agonist, (R)-3 -[[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]am...
متن کاملPreclinical assessment of potential interactions between botulinum toxin and neuromodulation for bladder micturition reflex
BACKGROUND While botulinum toxin A (BoNT-A) has become a more commonly used second-line treatment for patients with detrusor overactivity, it remains unknown whether the impacts of this therapy may persist to influence other therapies such as sacral neuromodulation. In this preclinical study we have evaluated urodynamic functions to intradetrusor injection of BoNT-A and the bladder inhibitory e...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2013
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2013.139